Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
USERS' SCORE
Good
Based on 172 Reviews
8.3
Supplement Facts
Serving Size: 2 Veggie Capsules
Amount Per Serving
%DV
BioCell Collagen®(from chicken sternal cartilage) providing minimum:Hydrolyzed Collagen Type IIChondroitin SulfateHyaluronic Acid
1000 mg600 mg200 mg100 mg
††††
Top Medical Research Studies
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
Read More
2
We assessed the effectiveness of hyaluronic acid (HA) injections for lumbar facet joint arthritis in a small pilot study involving thirteen patients. Each participant underwent a thorough evaluation before treatment, using questionnaires to gauge pain levels and disability. After a precise HA injection, we followed up with evaluations six weeks later.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Read More
Most Useful Reviews
10
Pain-free joints
68 people found this helpful
This product is incredible! I can't say enough about its impact on joint pain. After halting my runs due to severe hip pain, I've been pain-free for a month since taking this. No more stiffness in my ankles or knees in the morning. I forgot to take it for four days and noticed stiffness returning, but after resuming, my joints feel revitalised. I'm truly impressed by its effectiveness.
Read More
9
Pain-free knees
28 people found this helpful
For joints and skin, I can’t praise this product enough. My knee pain has vanished, and I’ve completely forgotten I even had issues with my knees.
Read More
9
Knee pain relief
26 people found this helpful
After just three days, my knee pain, which had troubled me for four years, faded away. I was searching for a solution beyond mere pain relief. This product worked on repairing my joints, and I wish I had tried it sooner. It feels incredible not to suffer from pain anymore!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
6.6
- All Researches
9
We examined how cross-linked hyaluronic acid (cHA) hydrogel can help reduce epidural fibrosis after back surgeries, which is a common cause of ongoing pain. In our study with rat models, we compared groups that received cHA to those that did not.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
The results showed that cHA treatment led to lower levels of fibrosis and overall healthier spinal structures. The treated groups had more space around the spinal cord and less thickening of protective membranes. Overall, we found that cHA is promising for managing post-surgical back pain by effectively reducing scar tissue formation.
Read More
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Read More
8
We examined the effects of hyaluronic acid in healing back pain linked to disc degeneration. In our study, New Zealand white rabbits undergoing a partial nucleotomy received either PGA/HA implants or bioactivated fibrin, while controls underwent the procedure without any treatment.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
Our results indicated that the use of PGA/HA implants led to more effective tissue repair, evidenced by a significant increase in type II collagen content, compared to the untreated controls. However, there was no change in the water content of the discs over the six-month period, highlighting that while tissue repair may improve, it may not directly enhance disc hydration or overall disc function.
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8
Sacroiliac joint pain treatment review
We explored the complex nature of chronic pain in the sacroiliac joint, which has long sparked debate due to its anatomical position. This makes accurate diagnosis challenging, often requiring advanced techniques like guided injections.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
While there are various treatment options available for sacroiliac joint syndrome, no single method has proven to be ideal. However, using hyaluronic acid through intra-articular viscosupplementation has shown promise in delivering long-lasting pain relief, promoting healthy joint function, and enhancing synovial fluid properties.
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7
Safety and feasibility confirmed
We explored the safety and feasibility of using hyaluronic acid alongside specially prepared stem cells to treat chronic low back pain. In a small study involving eight patients, everyone received a single injection while being monitored over six months.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Thankfully, there were no reported complications, and six out of eight participants showed meaningful improvements in pain and disability scores. While radiological changes were noted in four patients, the overall findings highlight the potential of this treatment as a safe option for chronic disc-related pain. However, further research is needed to confirm its effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 172 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Pain-free joints
68 people found this helpful
This product is incredible! I can't say enough about its impact on joint pain. After halting my runs due to severe hip pain, I've been pain-free for a month since taking this. No more stiffness in my ankles or knees in the morning. I forgot to take it for four days and noticed stiffness returning, but after resuming, my joints feel revitalised. I'm truly impressed by its effectiveness.
Read More
9
Pain-free knees
28 people found this helpful
For joints and skin, I can’t praise this product enough. My knee pain has vanished, and I’ve completely forgotten I even had issues with my knees.
Read More
9
Knee pain relief
26 people found this helpful
After just three days, my knee pain, which had troubled me for four years, faded away. I was searching for a solution beyond mere pain relief. This product worked on repairing my joints, and I wish I had tried it sooner. It feels incredible not to suffer from pain anymore!
Read More
9
Knee pain relief
23 people found this helpful
I've been taking this for about eight months, particularly for my knees. As a cyclist with arthritis, I faced considerable knee pain that hindered my riding. This product has evidently helped regenerate cartilage, something doctors deemed impossible. It has worked wonders for me, and I’ll continue taking it.
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10
Shoulder pain recovery
18 people found this helpful
This product truly works! I began taking it three weeks before my surgery and have experienced incredible results. While others from the surgery are still struggling, I’m already back in regular shoes, and my shoulder pain from an old injury has also disappeared. I'm convinced this helped speed up my recovery.
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Frequently Asked Questions
9
Back pain relief
11 people found this helpful
After only ten days of taking this, I noticed a significant reduction in back pain and almost no morning stiffness. I will certainly finish the entire jar, which lasts three months, and I'm very pleased with my purchase!
9
Back pain relief
10 people found this helpful
Excellent! After two weeks, my back pain diminished, and even my yoga improved. At almost 40, with disc issues, I noticed that my big toe pain disappeared too. I also feel my skin looks better. Don't hesitate, this really works!
8
Knee pain alleviated
5 people found this helpful
My knee had been painful while sitting or walking long distances. After following the suggested dosage, I noticed a significant reduction in pain by the fourth day. I’ve since had more comfortable journeys and plan to share this with family!
9
Knee pain relief
5 people found this helpful
There is a definite effect! I took hyaluronic acid with collagen for severe knee pain. After three months, my pain ceased, and my skin improved. I didn't expect such results, but I now plan to continue for another three months. No bad aftertaste and great convenience!
9
Knee pain relief
26 people found this helpful
After just three days, my knee pain, which had troubled me for four years, faded away. I was searching for a solution beyond mere pain relief. This product worked on repairing my joints, and I wish I had tried it sooner. It feels incredible not to suffer from pain anymore!
9
Knee pain improvement
14 people found this helpful
This product has been a revelation for my arthritis. My doctor suggested knee replacement surgery due to severe arthritis pain, but after just three days on this supplement, I felt mostly pain-free. It significantly aided my knee movement. I wish more doctors knew about it!
9
Knee pain relief
23 people found this helpful
I've been taking this for about eight months, particularly for my knees. As a cyclist with arthritis, I faced considerable knee pain that hindered my riding. This product has evidently helped regenerate cartilage, something doctors deemed impossible. It has worked wonders for me, and I’ll continue taking it.
9
Shoulder pain relief
17 people found this helpful
Hyaluronic acid has been fantastic. I suffered a shoulder joint injury, which made lifting my arm painful. After a few days on this medication, the pain disappeared and my mobility was fully restored. I highly recommend this to anyone with similar issues!
9
Back pain relief
9 people found this helpful
Super!!! I take two capsules with collagen, and I’m thrilled! My nails are stronger, hair loss has decreased, and my back pain is gone after a day!
9
Eliminated pain
9 people found this helpful
I thought surgery was unavoidable, but after combining this with bromelain, my knee pain completely vanished, allowing me to function without pain. This is an excellent product.
7.5
Effective for joints
10 people found this helpful
An excellent alternative to Theraflex for joint pain. Taking two tablets in the morning and one at night reduced my joint pain significantly. It contains glucosamine sulfate, which is better absorbed than other forms. My family and I find it provides great value.
9
Reduced inflammation
4 people found this helpful
An excellent product! My knee was inflamed and painful previously. After resuming intake post-crisis, I am nearly pain-free. It has clearly made a difference in my condition, especially since I suffer from advanced arthrosis.
7
We explored the impact of combining therapeutic exercise with dietary supplements, including hyaluronic acid, on chronic low back pain. In this study, 60 patients were split into two groups—one receiving only exercise and the other incorporating these supplements.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
The results showed that those taking supplements, alongside their exercise regimen, experienced more significant relief from pain and improved quality of life compared to those who exercised alone. Thus, using hyaluronic acid with rehabilitation exercises could be a beneficial approach for managing chronic low back pain.
7
We explored how a combination of physical activity and the dietary supplement Cartilox, which includes hyaluronic acid, affects back pain in patients with osteoarthritis. Our study involved 60 patients who received either Cartilox or no supplement alongside their therapy.
While the results suggest that Cartilox could be beneficial for individuals experiencing mild back pain, it appears its effectiveness may not be sufficient to replace non-steroidal anti-inflammatory drugs (NSAIDs) completely.
Overall, we found no adverse effects on biochemical markers, making Cartilox a viable option for patients, including those with other health conditions.
While the results suggest that Cartilox could be beneficial for individuals experiencing mild back pain, it appears its effectiveness may not be sufficient to replace non-steroidal anti-inflammatory drugs (NSAIDs) completely.
Overall, we found no adverse effects on biochemical markers, making Cartilox a viable option for patients, including those with other health conditions.
9
We conducted a study to explore whether intraarticular injections of hyaluronic acid (HA) could effectively treat chronic, nonradicular low back pain as compared to glucocorticoids. Sixty patients participated in a well-structured clinical trial where they received either HA or glucocorticoid injections.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
Both treatments resulted in significant pain relief, improved function, and enhanced quality of life. Notably, HA was found to be just as effective as glucocorticoids, and showed even better long-term benefits without any reported side effects.
7
Hyaluronic acid shows limited benefit
We evaluated the safety and effectiveness of injecting mesenchymal precursor cells and hyaluronic acid (HA) in individuals suffering from chronic low back pain linked to degenerative disc disease. In a multicenter study involving 100 participants, we measured their pain and disability levels using visual scales and questionnaires at various intervals over three years.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
Unfortunately, our findings did not show significant improvements in back pain relief attributable to HA. While there were some safety and effectiveness indicators for the treatment, the overall benefits of HA weren't substantial enough to draw strong conclusions.
2
We assessed the effectiveness of hyaluronic acid (HA) injections for lumbar facet joint arthritis in a small pilot study involving thirteen patients. Each participant underwent a thorough evaluation before treatment, using questionnaires to gauge pain levels and disability. After a precise HA injection, we followed up with evaluations six weeks later.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
Unfortunately, our findings indicated that there was no significant improvement in back pain or symptoms following the treatment. This suggests that HA may not be effective for managing lumbar facet joint arthritis at this stage.
References
- Lee DH, Park KS, Shin HE, Kim SB, Choi H, et al. Safety and Feasibility of Intradiscal Administration of Matrilin-3-Primed Adipose-Derived Mesenchymal Stromal Cell Spheroids for Chronic Discogenic Low Back Pain: Phase 1 Clinical Trial. Int J Mol Sci. 2023;24. 10.3390/ijms242316827
- Goode AP, Cleveland RJ, Kraus VB, Taylor KA, George SZ, et al. Biomarkers and longitudinal changes in lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2023;31:809. 10.1016/j.joca.2023.02.005
- Shavlovskaya OA. [Complex effects of physical exertion with dietary supplements Cartilox in pain syndrome effectiveness and safety evaluation]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99:20. 10.17116/kurort20229904120
- Baroncini A, Maffulli N, Eschweiler J, Knobe M, Tingart M, et al. Management of facet joints osteoarthritis associated with chronic low back pain: A systematic review. Surgeon. 2021;19:e512. 10.1016/j.surge.2020.12.004
- Farì G, Santagati D, Pignatelli G, Scacco V, Renna D, et al. Collagen Peptides, in Association with Vitamin C, Sodium Hyaluronate, Manganese and Copper, as Part of the Rehabilitation Project in the Treatment of Chronic Low Back Pain. Endocr Metab Immune Disord Drug Targets. 2022;22:108. 10.2174/1871530321666210210153619
- Amirdelfan K, Bae H, McJunkin T, DePalma M, Kim K, et al. Allogeneic mesenchymal precursor cells treatment for chronic low back pain associated with degenerative disc disease: a prospective randomized, placebo-controlled 36-month study of safety and efficacy. Spine J. 2021;21:212. 10.1016/j.spinee.2020.10.004
- Annaswamy TM, Armstead C, Carlson L, Elkins NJ, Kocak D, et al. Intra-articular Triamcinolone Versus Hyaluronate Injections for Low Back Pain With Symptoms Suggestive of Lumbar Zygapophyseal Joint Arthropathy: A Pragmatic, Double-Blind Randomized Controlled Trial. Am J Phys Med Rehabil. 2018;97:278. 10.1097/PHM.0000000000000879
- Kumar H, Ha DH, Lee EJ, Park JH, Shim JH, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study. Stem Cell Res Ther. 2017;8:262. 10.1186/s13287-017-0710-3
- Wu CY, Huang YH, Lee JS, Tai TW, Wu PT, et al. Efficacy of topical cross-linked hyaluronic acid hydrogel in preventing post laminectomy/laminotomy fibrosis in a rat model. J Orthop Res. 2016;34:299. 10.1002/jor.23001
- Endres M, Zenclussen ML, Casalis PA, Freymann U, Gil Garcia S, et al. Augmentation and repair tissue formation of the nucleus pulposus after partial nucleotomy in a rabbit model. Tissue Cell. 2014;46:505. 10.1016/j.tice.2014.09.003
- Cleary M, Keating C, Poynton AR. Viscosupplementation in lumbar facet joint arthropathy: a pilot study. J Spinal Disord Tech. 2008;21:29. 10.1097/BSD.0b013e318057720c
- Fuchs S, Erbe T, Fischer HL, Tibesku CO. Intraarticular hyaluronic acid versus glucocorticoid injections for nonradicular pain in the lumbar spine. J Vasc Interv Radiol. 2005;16:1493.
- Calvillo O, Skaribas I, Turnipseed J. Anatomy and pathophysiology of the sacroiliac joint. Curr Rev Pain. 2000;4:356.
- Srejic U, Calvillo O, Kabakibou K. Viscosupplementation: a new concept in the treatment of sacroiliac joint syndrome: a preliminary report of four cases. Reg Anesth Pain Med. 1999;24:84.
